AI Article Synopsis
- The study evaluated the effectiveness of Foundation Medicine's genomic profiling test using Next-Generation Sequencing (NGS) compared to standard molecular testing in cancer treatment.
- Only 12% of patients showed a significant change in their therapy based on the FM test results, despite identifying a variety of oncogenic mutations.
- While NGS can offer more testing options, the research indicates that its clinical benefits may primarily apply to a small fraction of patients, making current routine testing a more practical choice for many.
Article Abstract
Background: The use of Next-Generation Sequencing (NGS) has recently allowed significant improvements in cancer treatment. Foundation Medicine (FM) provides a genomic profiling test based on NGS for a variety of cancers. However, it is unclear if the Foundation Medicine test would result in a better outcome than the standard on-site molecular testing. In this retrospective chart review, we identified the FM cases from an academic Canadian hospital and determined whether these test results improved treatment options for those patients.
Materials And Methods: A retrospective analysis was performed on patients with solid tumors who had FM testing between May 1, 2014 and May 1, 2018. Clinical factors and outcomes were measured using descriptive statistics using Microsoft Excel Software.
Results: Out of 66 FM tests, eight patients (= 12%) had a direct change in therapy based on the FM tests. Identified were 285 oncogenic mutations (median 1, range 0-31); where TP53 (n = 31, 10.9%), CDKN2A (n = 19, 6.7%), KRAS (n = 16, 5.6%) and APC (n = 9, 3.2%) were the most common FM mutations identified.
Conclusion: A small proportion of FM reports identified actionable mutations and led to direct treatment change. FM testing is expensive and a few of the identified mutations are now part of routine on-site testing. NGS testing is likely to become more widespread, but this research suggests that its true clinical impact may be restricted to a minority of patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350441 | PMC |
| http://dx.doi.org/10.3389/fonc.2021.687730 | DOI Listing |
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