Introduction And Importance: Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunohistochemical features of histiocytes. It is characterized typically by extranodal presentation and a poor clinical course, particularly in cases with disseminated disease.

Case Presentation: This report documents a case of bifocal and aggressive HS in small bowel and lung revealed by acute peritonitis in a 63-year-old man.

Clinical Discussion: Despite its rarity, we believe that the correct diagnosis of HS is crucial for clinical treatment and prognostic prediction.

Conclusion: The collection of additional cases of HS are important to obtain further progress in prognosis and guide treatment decisions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339142PMC
http://dx.doi.org/10.1016/j.amsu.2021.102638DOI Listing

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