AI Article Synopsis
- The study aimed to evaluate how Epstein-Barr virus (EBV) behaves in the saliva and blood of HIV-positive patients, particularly in relation to oral hairy leukoplakia (OHL).
- It involved 94 patients, examining their blood and saliva for EBV levels and considering factors like age, gender, and HIV treatment history.
- Findings showed higher EBV levels in saliva, a correlation between EBV in saliva and blood, and that patients with OHL had significantly higher EBV in saliva, though OHL's presence was mainly linked to age rather than other HIV-related factors.
Article Abstract
Objective: To assess the oral shedding and viremia of Epstein-Barr virus (EBV) in HIV-positive patients and their relationship with oral hairy leukoplakia (OHL).
Methodology: A total of 94 HIV-positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T-cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization.
Results: The EBV load in the 94 HIV-positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (p = 0.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log = 3.11) compared to those who had no OHL (p = 0.045). Presence of OHL was only associated with age (p = 0.030).
Conclusion: In HIV-positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells.
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| http://dx.doi.org/10.1111/odi.14001 | DOI Listing |
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