Severe Sepsis: The Fragile Anatomy of Crude Mortality. | LitMetric

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session1h3clit29g2t9e4qtn6rvcsajhgtdlpv): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 197

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Severe Sepsis: The Fragile Anatomy of Crude Mortality. | LitMetric

Severe Sepsis: The Fragile Anatomy of Crude Mortality.

Nicole C Vissichelli Adam P Sima Richard P Wenzel

Clin Infect Dis

Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia, USA.

Published: October 2021

Clinical trials of severe sepsis that target crude mortality are underpowered to detect mortality differences due to intervention. We discuss the importance of including subcomponents of crude mortality in study design; how the proportion of attributable mortality affects sample size requirements; and how minor changes from predicted outcomes affect interpretation.

Download full-text PDF	Source
http://dx.doi.org/10.1093/cid/ciab677	DOI Listing

Publication Analysis

Top Keywords

crude mortality

12

severe sepsis

8

mortality

5

sepsis fragile

4

fragile anatomy

4

anatomy crude

4

mortality clinical

4

clinical trials

4

trials severe

4

sepsis target

4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!