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What men want: Results from a national survey on decision making for prostate cancer treatment and research participation. | LitMetric

AI Article Synopsis

  • - The study involved creating a 28-question survey to understand how men aged 50+ make treatment decisions for prostate cancer, focusing on the influence of various factors on their choices.
  • - Key findings revealed that long-term clinical outcomes were prioritized by respondents when deciding on treatment, while side effects greatly influenced their choices.
  • - Many men expressed reluctance to participate in randomized trials, showing a preference for more controlled treatment options, which suggests that engaging patients in trial design could improve participation rates and outcomes.

Article Abstract

Data comparing outcomes in prostate cancer and factors affecting treatment choice are sparse. To inform the design of a comparative effectiveness clinical trial, we engaged patients in developing a 28-question survey about decision making on treatment and research participation and dispersed it among men greater than or equal to 50 years of age. The 1046 respondents ranked long-term clinical outcomes as most important in making treatment decisions, specific functional outcomes as slightly less important, and duration, location, and cost of treatment as least important. Treatment choice was strongly impacted by side effect profile. Responses to whether the subject would agree to participation in a randomized trial between two types of radiation with minimal differences in outcomes were "yes" in 15%, "no" in 39%, and "undecided" in 46%. Responses to whether the subject would agree to participation in a randomized trial between two treatment durations with similar outcomes were yes in 36%, no in 24%, and undecided in 40%. Findings suggest many potential patients have strong treatment preferences and are averse to randomization, particularly when outcomes of importance may be affected. Patient engagement in study design and novel nonrandomized trial designs may offer a path to increase clinical trial success.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604236PMC
http://dx.doi.org/10.1111/cts.13090DOI Listing

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