Starting from the basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion distribution in bulk-milieu/membrane-interface and support the origin of trans-membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K > Na > Mg > Ca ) and outside (Na > K > Ca > Mg ). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based on murburn bioenergetic equilibriums leading to solubilization of ion-pairs, membrane's permittivity, protein channels' fluxes, and proteins' innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.
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Article Synopsis
- Contemporary beliefs about oxygenic photosynthesis are challenged, with the Murburn model presented as a new alternative explanation.
- In this model, reactive species play a key role, and all pigments are considered to be photo-redox active within a stochastic mechanism.
- NADPH is synthesized through straightforward electron transfers instead of a complex electron transport chain, and the model suggests a more dispersed oxygen production process.
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