Effect of controlled low central venous pressure technique on postoperative hepatic insufficiency in patients undergoing a major hepatic resection.

Objective: To investigate the effect of controlled low central venous pressure (CLCVP) technique on postoperative hepatic insufficiency in patients undergoing major hepatic resection.

Methods: In this single-center, propensity score matching, retrospective study, 331 patients who underwent laparoscopic major hepatectomy consecutively from October 1, 2014 to October 30, 2020 were enrolled and divided into a CLCVP group [0≤ central venous pressure (CVP) ≤5 cmHO] and normal CVP (NCVP) group (5< CVP ≤10 cmHO). The propensity score matching was used to adjust the differences in the data and was matched 1:1 to evaluate the impact of CLCVP on the incidence of liver insufficiency.

Results: After propensity score matching, 84 patients were included in each group, with a good balance of preoperative baseline and intraoperative data between the two groups. The incidence of postoperative hepatic insufficiency was 21.23% in the CLCVP group, which did not differ from that in the NCVP group (21.54%) (>0.05).

Conclusion: In patients undergoing laparoscopic major hepatectomy, CLCVP technique did not increase the incidence of postoperative hepatic insufficiency.