Background: Catheter-based renal denervation (RDN) has been introduced to treat resistant hypertension. Although the technology of RDN has been largely improved, denervation of tortuous renal arteries remains challenging.
Case Presentation: This is a case report of a 49-year-old man with drug resistant hypertension. The patient was selected for RDN after ruling out possible causes of secondary hypertension. Computed tomography angiography showed a highly tortuous left renal artery. An Iberis multielectrode ablation catheter failed to reach the target vessel with a regular guiding catheter. A 5-French extension catheter was introduced into the proximal segment of the main left renal artery to provide extra support force, which enabled successful ablation of the highly tortuous left renal artery. His ambulatory blood pressure was significantly decreased at 1 month follow-up.
Conclusions: It is feasible and effective to use a guide extension catheter for denervation of highly tortuous renal arteries. The present study provides a useful method to ablate tortuous and angled renal arteries and branches.
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http://dx.doi.org/10.1186/s12872-021-02199-9 | DOI Listing |
J Colloid Interface Sci
December 2024
School of Materials Science and Engineering, Ocean University of China, Qingdao 266404, China. Electronic address:
Thin yet robust solid-state electrolytes (SSEs) with efficient Li transport are highly desirable for realizing high-energy-density all-solid-state lithium-metal batteries (ASSLMBs). Herein, an ultrathin (10 μm) SSE with ordered ion pathways is reported for scalable ASSLMBs production. The SSE is supported by the poly (ether sulfone) scaffold, which not only improves mechanical strength and safety capability but also enables low-tortuous Li transport along the inner walls of its vertically aligned microchannels.
View Article and Find Full Text PDFJ Pharm Sci
November 2024
Drug Product and Device Development, Takeda Pharmaceutical Company, Lexington, MA, USA. Electronic address:
Although Closed System Transfer Devices (CSTDs) are used in oncology for dose preparation and administration, the impact of CSTDs on biologics and other non-small molecular modalities are not fully understood. We investigated particle formation when preparing and mock administering three experimental biologics (mAb, ADC, and fusion protein) using seven models of CSTDs. A wide range of visible and subvisible particle formation was observed among CSTD models.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
NCIM-Resource Center, Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Oil spillage is one of the serious problems for sustainable environment. Bacterial nanocellulose (BNC), a hydrophilic and highly porous material holds a promising material for oil-water separation from contaminants. In the present work, a hydrophilic BNC produced from a sorbitol as the carbon source demonstrated the unique porous symmetrical arrangement having an oleophilic property.
View Article and Find Full Text PDFSmall
November 2024
School of Materials Science and Engineering, Ocean University of China, Qingdao, 266404, China.
Sci Rep
November 2024
Medical Robotics and Automation (RoboMed) Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Minimally invasive procedures for endovascular interventions involve manual navigation of a guidewire. Endovascular interventions encompassing highly tortuous vessels would benefit from guidewires which exhibit higher dexterity. This paper introduces a version of the COAST (COaxially Aligned STeerable) guidewire system capable of exhibiting higher dexterity.
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