External assessment of the EUROMACS right-sided heart failure risk score.

Sci Rep

Department of Medicine, Division of Cardiology, University of Minnesota, 401 East River Parkway, Variety Club Research Center (VCRC), 1st Floor - Suite 131, Minneapolis, MN, 55455, USA.

Published: August 2021

The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98-2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52-66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352910PMC
http://dx.doi.org/10.1038/s41598-021-94792-3DOI Listing

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