AI Article Synopsis
- Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage, leading to symptoms like postural headaches and nausea due to low CSF volume.
- Imaging and clinical tests, including radioisotope scintigraphy, are vital for SIH diagnosis, though a significant number of patients don't show typical results.
- The study highlights that using conventional ELISA to measure total transferrin in CSF is a more accurate diagnostic tool for SIH and can identify cases with or without chronic subdural hematoma.
Article Abstract
Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30% of patients do not show typical morphology and clinical test results. We previously reported that CSF contains transferrin (Tf) isoforms:"brain-type" Tf derived from the choroid plexus and "serum-type" Tf derived from blood. We showed that both isoforms increased in the CSF of patients with SIH by Western blotting. In the present study, we demonstrate that conventional ELISA for quantifying total Tf is useful for diagnosing SIH more accurately than Western blotting. In addition, SIH with chronic subdural hematoma (CSDH) was also accurately diagnosed. Total Tf in the CSF can serve as a useful biomarker for diagnosing SIH with or without CSDH.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460282 | PMC |
| http://dx.doi.org/10.5387/fms.2020-19 | DOI Listing |
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