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Elevated cerebrospinal fluid biomarkers of neuroinflammation and neuronal damage in essential hypertension with secondary insomnia: Implications for Alzheimer's disease risk.
Brain Behav Immun
December 2024
Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China. Electronic address:
Essential hypertension (EH) with secondary insomnia is associated with increased risks of neuroinflammation, neuronal damage, and Alzheimer's disease (AD). However, its relationship with specific cerebrospinal fluid (CSF) biomarkers of neuronal damage and neuroinflammation remains unclear. This case-control study compared CSF biomarker levels across three groups: healthy controls (HC, n = 64), hypertension-controlled (HTN-C, n = 54), and hypertension-uncontrolled (HTN-U, n = 107) groups, all EH participants experiencing secondary insomnia.
View Article and Find Full Text PDFWearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.
J Affect Disord
December 2024
Mind-Body Interface Research Centre (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; An-Nan Hospital, China Medical University, Tainan, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:
Background: Device-based treatments exist in psychiatry for decades, but are usually operated by clinicians and require multiple office visits. Near-infrared transcranial photobiomodulation (tPBM) is a safe neurostimulation modality with potential antidepressant and hypnotic effects. We investigated the feasibility and efficacy of adjunctive tPBM treatment, self-administered by a wearable headband.
View Article and Find Full Text PDFMethodological and reporting recommendations for clinical trials in Nutritional Psychiatry: Guidelines from the International Society for Nutritional Psychiatry Research.
Br J Nutr
December 2024
Deakin University, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Food & Mood Centre, School of Medicine, Geelong, VIC, Australia.
Research on nutraceutical and dietary interventions in psychiatry has grown substantially, but progress is hindered by methodological inconsistencies and limited reporting standards. To address this, the International Society for Nutritional Psychiatry Research presents the first guidelines on clinical trial design, conduct, and reporting for future clinical trials in this area. Recommendations were developed using a Delphi process including eighteen researchers with considerable clinical trial expertise and experience in either methodology, nutraceutical, or dietary interventions in psychiatry.
View Article and Find Full Text PDFPharmacologic prophylaxis of postoperative delirium in elderly patients: A network meta-analysis of randomized controlled trials.
J Psychiatr Res
November 2024
Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan; An-Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address:
Article Synopsis
- The study addresses the high rates of postoperative delirium (POD) in elderly patients and seeks to evaluate the effectiveness of various pharmacological interventions to prevent it.
- A network meta-analysis was performed on 44 randomized controlled trials (RCTs) with 11,178 patients, focusing on the incidence of POD and tolerability of treatments.
- Results showed that atypical antipsychotics were the most effective in reducing delirium, while no significant differences were found in dropout rates or all-cause mortality among the treatment groups compared to placebo.
CATHARSIS BY KETAMINE TREATMENT.
Psychiatr Danub
May 2024
Mind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
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