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Cellular based immunotherapy for primary liver cancer. | LitMetric

Cellular based immunotherapy for primary liver cancer.

J Exp Clin Cancer Res

Department of Gastroenterology, Putuo People's Hospital, Tongji University, Shanghai, 200060, China.

Published: August 2021

Primary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for optimizations of the current conventional treatments and the exploration of novel therapeutic strategies. For most malignancies, including PLC, immune cells play crucial roles in regulating tumor microenvironments and specifically recognizing tumor cells. Therefore, cellular based immunotherapy has its instinctive advantages in PLC therapy as a novel therapeutic strategy. From the active and passive immune perspectives, we introduced the cellular based immunotherapies for PLC in this review, covering both the lymphoid and myeloid cells. Then we briefly review the combined cellular immunotherapeutic approaches and the existing obstacles for PLC treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351445PMC
http://dx.doi.org/10.1186/s13046-021-02030-5DOI Listing

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