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Simultaneously quantifying a novel five-component anti- migraine formulation containing ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine using UV spectrophotometry and chemometric models.
BMC Chem
November 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University -Kantara Branch, Ismailia, 341636, Egypt.
This study presents a new method for simultaneously quantifying a complex anti-migraine formulation containing five components (ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine) using UV spectrophotometry and chemometric models. The formulation presents analytical challenges due to the wide variation in component concentrations (ERG: PRO: CAF: CAM: MEC ratio of 0.075:20:8:5:4) and highly overlapping UV spectra.
View Article and Find Full Text PDFCorrection to: Anti-migraine agents from an immunological point of view.
J Transl Med
August 2021
Faculty of Applied Medical Sciences, Department of Medical Laboratory Technology, Immunology Group, King Abdul Aziz University, Jeddah, Saudi Arabia.
Advantages of imaging photoplethysmography for migraine modeling: new optical markers of trigemino-vascular activation in rats.
J Headache Pain
April 2021
Research Laboratory of Neuromodulation, Almazov National Medical Research Centre, Saint Petersburg, Russia.
Background: Existent animal models of migraine are not without drawbacks and limitations. The aim of our study was to evaluate imaging photoplethysmography (PPG) as a method of assessing intracranial blood flow in rats and its changes in response to electrical stimulation of dural trigeminal afferents.
Methods: Experiments were carried out with 32 anesthetized adult male Wistar rats.
Pharmacology of balance and dizziness.
NeuroRehabilitation
December 2013
Kessler Institute of Rehabilitation, West Orange, NJ 07052, USA.
Introduction: Dizziness and vertigo encompass a spectrum of balance-related symptoms caused by a variety of etiologies. Balance is affected by many systems: proprioceptive pathways, and visual, cerebellar, vestibulocochlear, and vascular/vasovagal systems. Treatment includes antihistamines, antiemetics, benzodiazepines, anti-inflammatory, anti-Meniere's, anti-migraine, antidepressants, anticonvulsants, and aminopyridines.
View Article and Find Full Text PDFTranscranial Direct Current Stimulation (tDCS) of the visual cortex: a proof-of-concept study based on interictal electrophysiological abnormalities in migraine.
J Headache Pain
March 2013
Headache Research Unit, Dept of Neurology, University of Liège, Liege, Belgium.
Background: Preventive pharmacotherapy for migraine is not satisfactory because of the low efficacy/tolerability ratio of many available drugs. Novel and more efficient preventive strategies are therefore warranted. Abnormal excitability of cortical areas appears to play a pivotal role in migraine pathophysiology.
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