AI Article Synopsis
- A large serological survey conducted in French Guiana from June to October 2017 assessed the burden of arboviral infections, testing 2,697 individuals for antibodies against DENV, CHIKV, ZIKV, and MAYV.
- The study found a high seroprevalence for DENV at 73.1%, with most individuals showing immunity to DENV-1, while lower seroprevalence was observed for CHIKV (20.3%), ZIKV (23.3%), and MAYV (3.3%).
- The findings highlight that a significant portion of the population is still susceptible to CHIKV and ZIKV, raising concerns about potential outbreaks, and emphasize
Article Abstract
Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6-75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7-23.1), 23.3% (20.9-25.9) and 3.3% (2.7-4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310293 | PMC |
| http://dx.doi.org/10.3390/v13071299 | DOI Listing |
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