Hydrogen sulfide (HS) is an important gasotransmitter in biological system, and plays a crucial role in varied physiological and pathological processes. Exogenous HS is widely employed as a positive control in HS related biological study. Herein, we develop a reactive oxygen species (ROS) triggered donor HSD545 that delivers HS and simultaneously generates a fluorophore to real-time monitoring the process of HS release in vitro and in vivo. The donor exhibits low cytotoxicity and strong cytoprotection against ROS-induce oxidative stress.
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| http://dx.doi.org/10.1016/j.saa.2021.120243 | DOI Listing |
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