A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines.

Chemistry

Instituto de Química Orgánica General, IQOG, Consejo Superior de Investigaciones Científicas, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.

Published: September 2021

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO CF groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519061PMC
http://dx.doi.org/10.1002/chem.202102254DOI Listing

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