Purpose: To report a case of severe stromal microsporidal keratitis successfully treated with oral albendazole and topical voriconazole.
Observations: A 71-year-old man presented with progressive vision loss and corneal opacification for one year. Initial visual acuity was counting fingers attributed to a dense subepithelial opacification. Confocal microscopy and subsequent corneal biopsy lead to the diagnosis of microsporidial keratitis. The patient completed a four-week course of oral albendazole and topical voriconazole which resulted in resolution of the corneal opacification and improvement in visual acuity to 20/250.
Conclusions And Importance: A four-week course of oral albendazole and topical voriconazole was an effective treatment for severe stromal microsporidial keratitis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326187 | PMC |
| http://dx.doi.org/10.1016/j.ajoc.2021.101178 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical characteristics, progression patterns and treatment outcomes in microsporidial keratoconjunctivitis: a prospective study in Thailand.
Int Ophthalmol
November 2024
Department of Ophthalmology, Phramongkutklao Hospital, 315 Ratchawithi Road, Thung Phayathai Subdistrict, Ratchathewi, Bangkok, 10400, Thailand.
Purpose: To assess the clinical characteristics, progression patterns, and treatment outcomes of microbiologically confirmed microsporidial keratoconjunctivitis (MKC).
Methods: This prospective cross-sectional study included patients with superficial punctate epithelial keratitis clinically suspected of MKC. Comprehensive slit-lamp examinations were conducted, and corneal scraping was performed for Gram-chromotrope staining and polymerase chain reaction (PCR) analysis.
[Advances in clinical diagnosis and treatment of microsporidial keratitis].
Zhonghua Yan Ke Za Zhi
October 2024
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.
Article Synopsis
- Microsporidia, a type of unicellular microorganism, can infect the eyes and lead to a condition known as microsporidia keratitis (MK), which has two forms: microsporidian keratoconjunctivitis (MKC) and stromal keratitis (MSK).
- MKC generally improves on its own, but can escalate to MSK, a severe condition that risks vision and could cause corneal perforation.
- Despite its prevalence in Southeast Asia, especially during the rainy season, there's a lack of detailed case reports and understanding of MK in China, resulting in challenges with diagnosis and treatment, which this review aims to address.
Microsporidial stromal keratitis: treatment outcomes, clinical manifestations, confocal microscopy and histopathology findings: a retrospective observational study.
BMJ Open Ophthalmol
September 2024
Ophthalmology, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
Objective: Microsporidial stromal keratitis (MSK) is an uncommon disease. Only several case series have been reported. We aimed to describe the clinical manifestations, histopathology and treatment outcomes of MSK.
View Article and Find Full Text PDFKeratic Precipitates: An Overlooked Sign of Microsporidial Stromal Keratitis?
Ocul Immunol Inflamm
November 2024
Cornea and Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, India.
Purpose: To elucidate a distinctive clinical feature in cases of microsporidial stromal keratitis (MSK).
Method: A retrospective observational study of cases with a histopathological and/or microbiological diagnosis of MSK on corneal biopsy or host corneal button between 2016 and 2022 was conducted.
Results: Eighteen cases with a confirmed histopathological and/or microbiological diagnosis of MSK were detected.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!