Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis . Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339579 | PMC |
| http://dx.doi.org/10.3389/fcell.2021.693533 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil.
Heliyon
December 2024
College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China.
Unlabelled: Patchouli oil (PO), extracted from Benth., a prominent aromatic plant of the Lamiaceae family, has shown considerable protective effects against gastrointestinal infections, particularly those induced by . This study aimed to develop a gastro-floating multi-unit system for PO to enhance its gastric retention and oral bioavailability.
View Article and Find Full Text PDFPatchouli essential oil extends the lifespan and healthspan of Caenorhabditis elegans through JNK-1/DAF-16.
Life Sci
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:
Aims: Patchouli essential oil (PEO) is the major active ingredient of a famous medicinal plant Pogostemon cablin (Blanco) Benth. This study aims to investigate the anti-aging activities of PEO and its major component, and elucidate the underlying molecular mechanisms.
Main Methods: The anti-aging activities of PEO and its main component patchouli alcohol (PA) were investigated by examining the lifespan, senescence associated indicators as well as stress resistance of Caenorhabditis elegans.
Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury via regulating endogenous corticosterone metabolism mediated by 11β-HSD1.
J Ethnopharmacol
February 2025
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:
Ethnopharmacological Relevance: Ulcerative colitis (UC), a chronic inflammatory bowel disease, has become a significant public health challenge due to the limited effectiveness of available therapies. Huoxiang Zhengqi (HXZQ), a well-established traditional Chinese formula, shows potential in managing UC, as suggested by clinical and pharmacological studies. However, the active components and mechanisms responsible for its effects remain unclear.
View Article and Find Full Text PDFProtective effects of patchouli alcohol against DSS-induced ulcerative colitis.
Sci Rep
July 2024
Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, No. 1, Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China.
Article Synopsis
- Patchouli alcohol (PA) is a special ingredient used in traditional Chinese medicine that can help with gut health.
- A study found that PA can reduce inflammation in mice with ulcerative colitis (UC) by lowering levels of certain harmful substances in the body.
- PA changes the makeup of gut bacteria but doesn't affect its overall diversity, and it helps protect the gut by targeting specific pathways related to inflammation.
The effect and mechanism of patchouli alcohol on cognitive dysfunction in AD mice induced by Aβ oligomers through AMPK/mTOR pathway.
Brain Res Bull
September 2024
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is a progressive brain disorder that affects memory, and the role of patchouli alcohol (PA) in treating it is not fully understood.
- This study used a mouse model of AD, induced by amyloid-beta (Aβ) and stimulated by lipopolysaccharide (LPS), to investigate PA's therapeutic effects on cognitive function and its mechanism in enhancing autophagy and reducing neuroinflammation.
- Findings showed that PA improved memory and cognitive impairments in mice and reduced microglial activation, likely by influencing the AMPK/mTOR signaling pathway to decrease neuroinflammation and enhance autophagy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!