AI Article Synopsis
- The skin is the largest organ and its dysfunction is linked to various diseases, emphasizing the need for new therapies for conditions like inflammatory diseases and hair loss.
- A systematic review analyzed 101 studies on the use of mesenchymal stromal cell (MSC)-conditioned medium (CM) for skin treatments, focusing on conditions such as wound healing, scars, and hair restoration.
- Results showed that MSC-CM improved various skin conditions in both animals and humans, making it a promising avenue for therapy, although further research is required for safety and standardization.
Article Abstract
The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343397 | PMC |
| http://dx.doi.org/10.3389/fcell.2021.654210 | DOI Listing |
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