New anti-reflux plastic stent to reduce the risk of stent-related cholangitis in the treatment of biliary strictures.

Background: There is little data available on the role of new anti-reflux plastic stents (ARPSs).

Aim: To compare the use of ARPSs with that of traditional plastic stents (TPSs) for patients with biliary strictures.

Methods: Consecutive patients with biliary strictures who underwent first endoscopic biliary stenting between February 2016 and May 2019 were included. The onset of stent-related cholangitis, stent patency, clinical success, and other adverse events were evaluated.

Results: Sixty-seven patients in the ARPS group and 66 patients in the TPS group were included in the final analyses. Fewer patients experienced stent-related cholangitis in the ARPS group than that in the TPS group (8 patients 18 patients; = 0.030). The median time till the onset of first stent-related cholangitis was later in the ARPS group than that in the TPS group (128.5 d 76 d; = 0.039). The cumulative median stent patency in the ARPS group was 185 d, which was significantly longer than that in the TPS group (133 d; = 0.001). The clinical success rates and other adverse events did not significantly differ between both groups.

Conclusion: Placement of new ARPS might be a safe and effective optional therapeutic strategy to reduce the risk of stent-related cholangitis and prolong stent patency.