The spread of infectious diseases arises from complex interactions between disease dynamics and human behavior. Predicting the outcome of this complex system is difficult. Consequently, there has been a recent emphasis on comparing the relative risks of different policy options rather than precise predictions. Here, one performs a parameter sweep to generate a large number of possible scenarios for human behavior under different policy options and identifies the relative risks of different decisions regarding policy or design choices. In particular, this approach has been used to identify effective approaches to social distancing in crowded locations, with pedestrian dynamics used to simulate the movement of individuals. This incurs a large computational load, though. The traditional approach of optimizing the implementation of existing mathematical models on parallel systems leads to a moderate improvement in computational performance. In contrast, we show that when dealing with human behavior, we can create a model from scratch that takes computer architectural features into account, yielding much higher performance without requiring complicated parallelization efforts. Our solution is based on two key observations. (i) Models do not capture human behavior as precisely as models for scientific phenomena describe natural processes. Consequently, there is some leeway in designing a model to suit the computational architecture. (ii) The result of a parameter sweep, rather than a single simulation, is the semantically meaningful result. Our model leverages these features to perform efficiently on CPUs and GPUs. We obtain a speedup factor of around 60 using this new model on two Xeon Platinum 8280 CPUs and a factor 125 speedup on 4 NVIDIA Quadro RTX 5000 GPUs over a parallel implementation of the existing model. The careful design of a GPU implementation makes it fast enough for real-time decision-making. We illustrate it on an application to COVID-19.
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http://dx.doi.org/10.1007/s41745-021-00250-4 | DOI Listing |
Genet Med
January 2025
Division of Human Genetics, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Purpose: Noonan syndrome and related disorders (NS) are multisystemic conditions affecting approximately 1:1000 individuals. Previous natural history studies were conducted prior to widespread comprehensive genetic testing. This study provides updated longitudinal natural history data in participants with molecularly confirmed NS.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Introduction: Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.
Methods: Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic).
Dev Sci
March 2025
Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
Newborns are able to neurally discriminate between speech and nonspeech right after birth. To date it remains unknown whether this early speech discrimination and the underlying neural language network is associated with later language development. Preterm-born children are an interesting cohort to investigate this relationship, as previous studies have shown that preterm-born neonates exhibit alterations of speech processing and have a greater risk of later language deficits.
View Article and Find Full Text PDFThorac Cancer
January 2025
Department of Thoracic Surgery, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.
Objective: Among the different subtypes of invasive lung adenocarcinoma, lepidic predominant adenocarcinoma (LPA) has been recognized as the lowest-risk subtype with good prognosis. The aim of this study is to provide insight into the heterogeneity within LPA tumors and to better understand the influence of other sub-histologies on survival outcome.
Methods: Overall, 75 consecutive patients with LPA in pathologic stage I (TNM 8th edition) who underwent resection between 2010 and 2022 were included into this retrospective, single center analysis.
Palliat Support Care
January 2025
Department of Palliative Medicine, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
Objectives: Wishes to hasten death (WTHDs) are common in patients with serious illness. The Schedule of Attitudes Toward Hastened Death (SAHD) is a validated 20-item instrument for measuring WTHD. Two short versions have also been developed based on statistical item selection.
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