Panel count data arise in many applications when the event history of a recurrent event process is only examined at a sequence of discrete time points. In spite of the recent methodological developments, the availability of their software implementations has been rather limited. Focusing on a practical setting where the effects of some time-independent covariates on the recurrent events are of primary interest, we review semiparametric regression modelling approaches for panel count data that have been implemented in R package spef. The methods are grouped into two categories depending on whether the examination times are associated with the recurrent event process after conditioning on covariates. The reviewed methods are illustrated with a subset of the data from a skin cancer clinical trial.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340851PMC
http://dx.doi.org/10.1111/insr.12271DOI Listing

Publication Analysis

Top Keywords

panel count
12
count data
12
semiparametric regression
8
recurrent event
8
event process
8
regression analysis
4
analysis panel
4
data
4
data practical
4
practical review
4

Similar Publications

Background: Severe COVID-19 presents a variety of clinical manifestations associated with inflammatory profiles. People living with HIV (PLWH) could face a higher risk of hospitalization and mortality from COVID-19, depending on their immunosuppression levels. This study describes inflammatory markers in COVID-19 clinical outcomes with and without HIV infection.

View Article and Find Full Text PDF

Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness.

J Am Coll Cardiol

January 2025

SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing, China; Research Station of Alpine Ecology Environment and Health at Tibet University, Lhasa, Tibet Autonomous Region, China. Electronic address:

Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.

Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.

View Article and Find Full Text PDF

Background: A dysbiotic vaginal microbiome (VMB) is associated with clinical conditions such as bacterial vaginosis (BV) and an increased risk of human immunodeficiency virus (HIV-1) infection. Considering the high prevalence of BV among African, Caribbean and Black (ACB) women, we conducted a prospective, randomized, open-label phase 1 clinical trial to determine the feasibility, safety and tolerability of administering low-dose estrogen, probiotics or both in combination to improve vaginal health and decrease HIV-1 susceptibility.

Methods: ACB women aged 18-49 from the Greater Toronto Area (GTA) were randomized to one of four study arms: intravaginal estradiol (Estring©; 7.

View Article and Find Full Text PDF

Introduction: Cesarean deliveries account for approximately one-third of all births in Germany, prompting ongoing discussions on cesarean section rates and their connection to medical staffing and birth volume. In Germany, the majority of departments integrate obstetric and gynecological care within a single department.

Methods: The analysis utilized quality reports from German hospitals spanning 2015 to 2019.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!