The article focuses on the fact that 2020 has become a new point in the history of mankind, irrevocably changing the ways of life accepted in society and forcing the entire population of the earth to live in a new way. If a person's health is threatened and / or worried about the thought of a terminal illness, it is difficult to focus on something else. Over the past year, many have experienced this reality for the first time. Effective January 30, 2020, the World Health Organization has declared the coronavirus outbreak a health emergency, causing international concern. The fact that some countries (New Zealand, Australia and South Korea) quickly contained the spread of the virus, but faced new, imported cases, leads to the conclusion that the victory over COVID-19 is possible only worldwide. And if in 2020 masks and social distancing were the methods of fighting the virus, then the main method of 2021 will be the vaccination of the inhabitants of the earth. However, here, too, the key factor is the scale of vaccination, which is one of the main factors in the effectiveness of the fight against any large-scale disease. Here, every person faces a moral and legal question: participation in vaccination is the right of every person as a bearer of human dignity, which implies the impossibility of taking any action on a person without his consent, or the duty of a member of society, which implies the need for vaccination as the question of the survival of the human race as a whole. The article draws attention to the refusal to vaccinate against measles in Ukraine and the consequences of such a choice. The reason for the lack of measles vaccination at the required epidemiological level in Ukraine is not the lack of the necessary vaccines, but the conscious choice of a negative model of behavior by the citizens of the country. The refusal to vaccinate children may be due to a psychological factor caused by the death of a student who was vaccinated against measles on the eve of death. At the same time, the media thirteen years after the event, conducting numerous medical examinations, provides fundamentally contradictory information about the causal relationship between the vaccination of a student against measles and his death. Based on the analysis, it was concluded that vaccination is the most effective way to prevent infection and severe outcomes caused by viruses. Despite this vaccination coverage against viral infections, seasonal influenza in many countries around the world remains low. Even if a vaccine is available to the citizens of a particular country, but educational programs are not carried out on the need and importance of vaccination, the potential for increasing vaccination rates against viruses will continually diminish. The most common explanation for the current upsurge in vaccine uncertainty is that the Internet enables vaccine deniers to reach out to a wide audience by publicizing their beliefs. Some activists only criticize some vaccines. Such a selective stance may indicate a communication strategy used to promote a particular vaccine. Attention should also be paid to the refusal to vaccinate due to the lack of acceptance by the human mind of traditional medicine, not belief in its effectiveness, the use of alternative, alternative medicine in the treatment of diseases. The reasons for not trusting the vaccination process are highlighted. These include: lack of trust in vaccine manufacturers who are economically motivated to make a profit; not trusting medical institutions that provide vaccinations and the conditions in which vaccines are stored; lack of confidence in government agencies involved in the procurement of vaccines, the possibility of corruption in case of abuse of their powers; fear of disease and side effects due to vaccination; distortion by the media of objective data on vaccination.
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Virol J
January 2025
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccines. We have previously developed an HPV 16 DNA vaccine encoding a modified E7/HSP70 (mE7/HSP70) fusion protein, which demonstrated significant antitumor effects in murine models.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Fukuoka, Japan.
Background: During the COVID-19 pandemic, information and circumstances changed from moment to moment, including the accumulation of scientific knowledge, the emergence of variants, social tolerance, and government policy. Therefore, it was important to adapt workplace countermeasures punctually and flexibly based on scientific evidence and according to circumstances. However, there has been no assessment of changes in workplace countermeasures.
View Article and Find Full Text PDFSci Rep
January 2025
School of Economics and Management, Beijing Jiaotong University, No.3 Shangyuan Cun, Haidian District, Beijing, 100044, People's Republic of China.
The outbreak of novel infectious diseases presents major public health challenges, highlighting the urgency of accelerating vaccination efforts to reduce morbidity and mortality. Vaccine allocation has become a crucial societal concern. This paper introduces a dynamic vaccine allocation model that considers demand uncertainty and vaccination willingness, focusing on the trade-off between fairness and efficiency.
View Article and Find Full Text PDFJ Cancer Educ
January 2025
Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
College men are among those least likely to be vaccinated against the human papillomavirus (HPV). Viewing digital stories from other college men who were vaccinated against HPV as young adults may help influence them to seek the vaccine. Guided by the Theory of Planned Behavior, this research reports on the creation and pilot testing of digital stories to increase college men's intentions to vaccinate against HPV.
View Article and Find Full Text PDFCurr Top Med Chem
January 2025
Australasian Nanoscience and Nanotechnology Initiative (ANNI), Monash University LPO, Clayton, VIC 3168, Australia.
Ongoing research and development efforts are currently focused on creating COVID-19 vaccines using a variety of platforms. Among these, mRNA technology stands out as a cuttingedge method for vaccine development. There is a growing public awareness of mRNA and its potential in vaccine development.
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