In childhood, infectious diseases, as a rule, are generalized in nature with the development of urgent or critical conditions that require the transfer of the child to mechanical ventilation. A child's stay on mechanical ventilation, on the one hand, is vital, on the other hand, it is a factor that threatens the development of acute encephalopathy, mechanical ventilation associated pneumonia, polyneuropathy and myopathy of critical conditions. According to the authors, the incidence of critical encephalopathy in patients with generalized infectious diseases who are on mechanical ventilation is 75%, and in the long-term (after 1 year) outcome in convalescents, the frequency of neurological deficit reaches 33%. In this regard, it is extremely important to timely diagnose and predict encephalopathy, including in children, as well as early adequate therapy with the inclusion of a complex action drug Cytoflavin, which has not only an antioxidant, antiplatelet effect, but also anti-inflammatory and remyelinating. The article presents a clinical case of critical state encephalopathy, which developed against the background of a severe infectious disease after artificial ventilation with effective timely use of Cytoflavin.
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Front Immunol
January 2025
Department of Medical Laboratory, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections pose a significant global healthcare challenge, particularly due to the high mortality risk associated with septic shock. This study aimed to develop and validate a machine learning-based model to predict the risk of MDR-KP-associated septic shock, enabling early risk stratification and targeted interventions.
Methods: A retrospective analysis was conducted on 1,385 patients with MDR-KP infections admitted between January 2019 and June 2024.
Front Pediatr
January 2025
Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: One of the most prevalent healthcare-associated infections in the pediatric intensive care unit is ventilator-associated pneumonia (VAP). VAP not only results in prolonged hospital and intensive care unit (ICU) stays but also imposes higher costs on patients and the healthcare system. Therefore, it is essential to implement preventive measures.
View Article and Find Full Text PDFMed Devices (Auckl)
January 2025
Department of Anesthesiology, Deyang People's Hospital, Deyang, 618000, People's Republic of China.
Purpose: Lung ultrasound (LUS) is increasingly utilized in the field of anesthesiology due to its focused, quick application and the advantage of not exposing patients to ionizing radiation. This study aims to analyze the status and trends in this area from a macroscopic perspective.
Methods: A bibliometric analysis was conducted using the Web of Science (WoS) Core Collection.
Front Cell Infect Microbiol
January 2025
Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Background: Community-acquired pneumonia (CAP) poses a significant health threat to the elderly population, leading to high morbidity and mortality rates. Serum ferritin, a critical indicator of iron metabolism, plays a pivotal role in inflammation and immune regulation. Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.
View Article and Find Full Text PDFInfect Drug Resist
January 2025
Infectious Diseases Unit, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Purpose: To describe the top three causative organisms of hospital acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in Thailand.
Patients And Methods: This multi-center retrospective cohort study included HAP/VAP patients hospitalized in 2019 in three university-affiliated hospitals and a private hospital in Bangkok, Thailand. Medical records of patients with a documented diagnosis of nosocomial pneumonia (NP) were systematically reviewed to collect data on demographic, clinical, microbiological, and 30-day readmission due to NP.
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