Comparative analysis of pulmonary nodules segmentation using multiscale residual U-Net and fuzzy C-means clustering.

Comput Methods Programs Biomed

Fujian Provincial Key Laboratory of Data Intensive Computing, Quanzhou Normal University, Quanzhou 362000, China; Key Laboratory of Intelligent Computing and Information Processing, Quanzhou Normal University, Fujian Province University, Quanzhou 362000, China; Faculty of Mathematics and Computer Science, Quanzhou Normal University, Quanzhou 362000, China. Electronic address:

Published: September 2021

Background And Objective: Pulmonary nodules have different shapes and uneven density, and some nodules adhere to blood vessels, pleura and other anatomical structures, which increase the difficulty of nodule segmentation. The purpose of this paper is to use multiscale residual U-Net to accurately segment lung nodules with complex geometric shapes, while comparing it with fuzzy C-means clustering and manual segmentation.

Method: We selected 58 computed tomography (CT) scan images of patients with different lung nodules for image segmentation. This paper proposes an automatic segmentation algorithm for lung nodules based on multiscale residual U-Net. In order to verify the accuracy of the method, we also conducted comparative experiments, while comparing it with fuzzy C-means clustering.

Results: Compared with the other two methods, the segmentation of lung nodules based on multiscale residual U-Net has a higher accuracy, with an accuracy rate of 94.57%. This method not only maintains a high accuracy rate, but also shortens the recognition time significantly with a segmentation time of 3.15 s.

Conclusions: The diagnosis method of lung nodules combined with deep learning has a good market prospect and can improve the efficiency of doctors in diagnosing benign and malignant lung nodules.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmpb.2021.106332DOI Listing

Publication Analysis

Top Keywords

lung nodules
24
multiscale residual
16
residual u-net
16
fuzzy c-means
12
nodules
9
pulmonary nodules
8
c-means clustering
8
comparing fuzzy
8
nodules based
8
based multiscale
8

Similar Publications

In this article, we report the first case of a 61-year-old woman who was diagnosed with both nodules and cystic lesions in her lungs. The lung nodules were diagnosed as ALK-positive histiocytosis (APH) carrying an gene fusion, which microscopically displayed a mixed morphology of foamy cells, spindle cells, and Touton's giant cells. Immunohistochemistry showed expression of CD163, CD68, and ALK, while fluorescence hybridization (FISH) with second-generation sequencing (NGS) showed the ALK gene fusion with the FLCN gene variant.

View Article and Find Full Text PDF

Pleomorphic adenoma of the trachea is a rare benign tumor, often challenging to diagnose due to nonspecific symptoms. We report a case of a 72-year-old female with a 10-year history of presumed bronchial asthma, presenting with persistent dyspnea. Preoperative assessment for breast cancer surgery revealed severe obstructive ventilatory impairment.

View Article and Find Full Text PDF

A 79-year-old man was found to have multiple nodules in the lung fields on chest computed tomography. Metastatic lung cancer was suspected; however, the primary site remained elusive. After 1 year of follow-up, both the nodules had enlarged.

View Article and Find Full Text PDF

Aspergillosis is the most commonly and widely reported fungal infection in birds. Disease development is often secondary to stressors that cause immunocompromise, and it is typically regarded as a disease of captivity. We retrospectively evaluated data from 133 birds diagnosed with aspergillosis at the Southeastern Cooperative Wildlife Disease Study from 2001-2023 to assess diversity and relative frequency across avian taxa, gross and histologic lesion patterns, and comorbidities.

View Article and Find Full Text PDF

Neutrophil extracellular traps promote growth of lung adenocarcinoma by mediating the stability of m6A-mediated SLC2A3 mRNA-induced ferroptosis resistance and CD8(+) T cell inhibition.

Clin Transl Med

February 2025

The Second Department of Thoracic Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan Province, P.R. China.

To investigate the potential mechanisms underlying neutrophil extracellular traps (NETs) confer ferroptosis resistance and CD8(+) T cell inhibition in lung adenocarcinoma (LUAD). By the intravenous injection of LLC cells into the tail vein, a LUAD mouse model was created. Phorbol-12-myristate-13-acetate (PMA) stimulated neutrophils to facilitate NETs formation and combined with NETs inhibitor DNase I to explore NETs mechanism on LLC cell proliferation, migration, ferroptosis resistance, and CD8(+) T cell activity.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!