Altered HS levels and intracellular viscosity have both been seen in Parkinson's disease (PD). However, how HS and intracellular viscosity are involved in PD pathogenesis remains unknown. Herein, a dual-function fluorescent probe DF was designed and synthesized to analyze intracellular viscosity and hydrogen sulfide. It is a near-infrared fluorescence probe with improved photostability and large Stokes shift (110 nm). The probe reveals increased viscosity and hydrogen sulfide in zebrafish model of PD for the first time.
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| http://dx.doi.org/10.1016/j.talanta.2021.122621 | DOI Listing |
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