It is shown that during 10 days after transplantation of syngenic 22a hepatoma cells to C3HA mice, wave-like fluctuations of the natural killer cell (NK) activity of splenocytes take place. Xenogenic (K-562) and allogenic (AC-1) cells are used as target cells in the 18th hour 3H-uridine cytotoxic test. A significant increase in the NK-activity on the 2nd-3rd and 7-9th days after tumour cells transplantation is observed. Elimination of adherent cells from suspension of splenocytes lead to an increase in the NK-activity especially on the 7th-9th days.
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