-Dependent Transcriptome Regulation in the Melanocyte Lineage and in Melanoma.

The precise role played by the tumor suppressor gene in melanocyte biology and during the transformation into melanoma is not completely understood. In particular, understanding the interaction during melanocyte development between and key signaling pathways, which are known to be reactivated in advanced melanoma, is still under investigation. Here, we used RNAseq datasets from either situation to better understand the transcriptomic regulation mediated by an partial loss of function. We found that mutations had a differential impact on pluripotency and on melanoblast differentiation. In addition, major signaling pathways such as VEGF, senescence/secretome, endothelin, and cAMP/PKA are likely to be upregulated upon loss of function in both melanoblasts and metastatic melanoma. In sum, these data bring new light on the transcriptome regulation of the -mutated melanoma subgroup and will help improve the possibilities for specific treatment.