Aims: The clinical role of the left atrial (LA) hypertension in patients with atrial fibrillation (AF) and its role as predictor in those undergoing pulmonary vein (PV) isolation is still unknown. The aim of the present study was to analyze the role of LA pressure in patients with nonvalvular AF who underwent PV isolation and its implication for AF catheter ablation.
Methods: Consecutive patients with drug resistant AF who underwent PV isolation at San Maurizio Regional Hospital of Bolzano (Italy) as index procedure were included in this analysis.
Results: A total of 132 consecutive patients (97 males, 73%; mean age 58.0 ± 13.2 years) were included in the analysis. Eleven patients (8%) underwent radiofrequency ablation and 121 (92%) cryoballoon ablation. Higher LA pressures were found in 54 patients (40.9%). At a mean follow up of 14.3 ± 8.2 months (median 12 months), the success rate without antiarrhythmic therapy was 65.9% (87/132; considering the blanking period). Female gender and continuous mean LA pressure were significantly associated with AF recurrence and remained significant on multivariable Cox analysis (respectively, HR 1.845, 1.00-3.40, = 0.05 and HR 1.066, 1.002-1.134, = 0.04). We identified a LA mean pressure of >15 mmHg as ideal cutoff and constructed a model to predict AF recurrence which fitted with a concordance index (C-index) of 0.65 (95% CI 0.56-0.75), logrank score = 0.003.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348802 | PMC |
| http://dx.doi.org/10.3390/jcm10153208 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Arterial Stiffness and Markers of Atrial Myopathy.
Ann Noninvasive Electrocardiol
March 2025
Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Background: Arterial stiffness, measured using carotid-femoral pulse wave velocity (c-f PWV) and heart rate-corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (AF). In this cross-sectional study, we aimed to investigate whether arterial stiffness is associated with markers of atrial myopathy, which refers to structural and electrical changes in the atria that indicate increased AF risk.
Methods: We included 1050 participants (age 57 ± 4.
Ultra High-Density Mapping and Ablation of Localized Micro-Reentrant Tachycardias: Insight From the CHARISMA Registry.
J Cardiovasc Electrophysiol
January 2025
Cardiology department, "S. Maria dei Battuti" Hospital, Via Brigata Bisagno, Conegliano (TV), Italy.
Background: Recent advancements in ultra-high-density mapping (UHDM) featuring automated functionalities have enhanced our understanding of micro-reentrant atrial tachycardias (mAT) circuits and the precise localization of the origin.
Purpose: To evaluate the diagnostic support provided by an automated UHDM algorithm in guiding the ablation of mATs.
Methods: Consecutive patients eligible for AT ablation in 22 Italian centers were prospectively enrolled.
In Vivo Effects of Cardiomyocyte-Specific Beta-1 Blockade on Afterload- and Frequency-dependent Cardiac Performance.
Am J Physiol Heart Circ Physiol
January 2025
Department of Cardiovascular Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Pharmacologic beta-blockade is a well-established therapy for reducing adverse effects from sympathetic overactivity in cardiovascular diseases, such as heart failure. Despite decades of research efforts, in vivo cardiac functional studies utilizing genetic animal models remain scant. We generated a mouse model of cardiomyocyte-specific deletion of beta-1 adrenergic receptor (ADRB1) , the primary subtype expressed in cardiac myocytes, and demonstrated the role for ADRB1 in the maintenance of cardiac function at baseline and during exposure to increase in cardiac afterload by transient aortic occlusion and increasing heart rates (HRs) via atrial pacing.
View Article and Find Full Text PDFFirst-in-Human Helical-Fixation Leadless Pacemaker in the Left Atrium for D-Transposition With Atrial Switch Procedure.
JACC Case Rep
January 2025
Division of Cardiology, Electrophysiology Section, Adult Congenital Arrhythmia Clinic, Emory University, Atlanta, Georgia, USA.
Background: The atrial switch procedure is accompanied by a very high rate of sinus node dysfunction. Baffle stenosis is a common problem with transvenous pacemaker leads in this scenario.
Case Summary: We present a first-in-human case of a leadless pacer (LP) in the left atrium in a patient with prior atrial switch for transposition and sinus node dysfunction complicated by multiple abandoned leads, superior baffle occlusion, and failed extraction.
Comparative evaluation of left atrial size in healthy cats measured by two-dimensional echocardiography and cardiovascular MRI.
J Feline Med Surg
January 2025
College of Veterinary Medicine, China Agricultural University, Beijing, China.
Objectives: This study aimed to assess left atrial (LA) size in healthy cats using cardiovascular MRI (cMRI) and to compare this with LA size assessed by two-dimensional echocardiography. The hypothesis was that cMRI would accurately determine LA size in domestic cats.
Methods: A prospective comparative study was performed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!