Antiallergic Activity of 6-Deoxy-2--methyl-6-(-hexadecanoyl)amino-l-ascorbic Acid.

Molecules

Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka-cho, Shobara, Hiroshima 727-0023, Japan.

Published: August 2021

Allergy is an excessive immune response to a specific antigen. Type I allergies, such as hay fever and food allergies, have increased significantly in recent years and have become a worldwide problem. We previously reported that an ascorbic acid derivative having palmitoyl and glucosyl groups, 2--α-d-glucopyranosyl-6--hexadecanoyl-l-ascorbic acid (6-sPalm-AA-2G), showed inhibitory effects on degranulation in vitro and on the passive cutaneous anaphylaxis (PCA) reaction in mice. In this study, several palmitoyl derivatives of ascorbic acid were synthesized and a structure-activity relationship study was performed to discover more potent ascorbic acid derivatives with degranulation inhibitory activity. 6-Deoxy-2--methyl-6-(-hexadecanoyl)amino-l-ascorbic acid (2-Me-6--Palm-AA), in which a methyl group was introduced into the hydroxyl group at the C-2 position of ascorbic acid and in which the hydroxyl group at the C-6 position was substituted with an -palmitoyl group, exhibited much higher inhibitory activity for degranulation in vitro than did 6-sPalm-AA-2G. 2-Me-6--Palm-AA strongly inhibit the PCA reaction in mice at lower doses than those of 6-sPalm-AA-2G. These findings suggest that 2-Me-6--Palm-AA may be a promising therapeutic candidate for allergic diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348947PMC
http://dx.doi.org/10.3390/molecules26154684DOI Listing

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