Structural Characterization of a Polysaccharide from and Its Bioactivity on Gut Microbiota.

Molecules

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Published: July 2021

AI Article Synopsis

  • A new homogeneous polysaccharide was isolated from a specific source using hot-water extraction, ethanol precipitation, and a membrane separator, with a molecular weight of 20.1 kDa and a glucose-only composition.
  • Structural analysis revealed it contains various types of linked glucose units and branches of citric acid and -hydroxybenzyl alcohol.
  • Bioactivity tests indicated that this polysaccharide can significantly enhance the growth of certain bacterial strains, suggesting its potential health benefits in modulating gut microbiota.

Article Abstract

A novel homogeneous polysaccharide named was isolated and purified from () by hot-water extraction, ethanol precipitation, and membrane separator. , which has a molecular weight of 20.1 kDa, contains a polysaccharide framework comprised of only glucose. Methylation and NMR analysis showed that contained 1,3,6-linked-α-Glc, 1,4-linked-α-Glc, 1,4-linked-β-Glc and 1,4,6-linked-α-Glc. Interestingly, contained citric acid and repeating -hydroxybenzyl alcohol as one branch. Furthermore, a bioactivity test showed that could significantly promote the growth of () and () strains. These results implied that might be useful for human by modulating gut microbiota.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348156PMC
http://dx.doi.org/10.3390/molecules26154443DOI Listing

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