Considering the role of magnesium in bone metabolism and the increasing relevance of plant-mediated green-synthesis, this work compares the bone cytocompatibility of magnesium hydroxide nanoparticles (NPs) produced by using pure water, Mg(OH), or a rosehip (RH) aqueous extract, Mg(OH)RH. The NPs were evaluated for dose- and time-dependent effects on human osteoblastic and osteoclastic response, due to the direct involvement of the two cell types in bone metabolism. Mg(OH) NPs presented nanoplatelet-like morphology (mean diameter ~90 nm) and a crystalline structure (XRD analysis); the RH-mediated synthesis yielded smaller rounded particles (mean diameter <10 nm) with decreased crystallinity. On the ATR-FTIR spectra, both NPs presented the characteristic Mg-OH peaks; Mg(OH)RH exhibited additional vibration bands associated with the presence of phytochemicals. On osteoblastic cells, NPs did not affect cell growth and morphology but significantly increased alkaline phosphatase (ALP) activity; on osteoclastic cells, particles had little effect in protein content, tartrate-resistant acid phosphatase (TRAP) activity, percentage of multinucleated cells, and cell area. However, compared with Mg(OH), Mg(OH)RH increased osteoblastic differentiation by inducing ALP activity and promoting the expression of Runx2, SP7, Col1a1, and ALP, and had a negative effect on the expression of the osteoclastic genes NFATC1, CA2, and CTSK. These observations suggest the potential usefulness of Mg(OH)RH NPs in bone regeneration.
Jiangxi Key Laboratory of Environmental Pollution Prevention and Control in Mining and Metallurgy, Ganzhou, 341000, PR China; School of Resources and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou, 341000, PR China. Electronic address:
The coadsorption of anionic and cationic pollutants on adsorbents holds considerable importance in the development of relevant removal technologies and the understanding of pollutant transport in complex environmental media. Herein, tungsten (W), an emerging contaminant, and nickel (Ni) were chosen as two differently charged inorganic pollutants to investigate their removal characteristics on a magnesium-aluminum layered double hydroxide (LDH) prepared via microwave radiation. In the single systems, the amount of adsorbed W on LDH was initially increased and then decreased with increasing initial W concentration.
Background: Magnesium (Mg) and its alloys are promising candidates for biodegradable materials in next-generation bone implants due to their favourable mechanical properties and biodegradability. However, their rapid degradation and corrosion, potentially leading to toxic byproducts, pose significant challenges for widespread use.
Objectives: This study aimed to address the challenges associated with Mg-based materials by thoroughly evaluating the biocompatibility, genotoxicity, and mechanical properties of Mg-based devices manufactured via Single Point Incremental Forming (SPIF).
Autograft has traditionally been the preferred method for bone surgeries, but synthetic implants are gaining popularity due to better biosafety and standardized procedures.
Researchers developed a magnesium-impregnated membrane that releases magnesium ions to promote bone formation and studied its properties using advanced techniques like SEM and TGA.
The study showed that grafted magnesium hydroxide particles integrate well in rat skull defects, highlighting their potential for creating bio-friendly, effective biomedical materials.
At the Fukushima Daiichi Nuclear Power Station (FDNPS), continuous water circulation cools fuel debris, leading to the presence of radionuclides such as Sr-30, Cs-137, and I-129 in the cooling water. These radionuclides are adsorbed and co-precipitated by various materials. Among them, I-129 is a key radionuclide for safety assessment during the final disposal of adsorbent and co-precipitation materials, owing to its long half-life and poor sorption.
