AI Article Synopsis
- * Various viral infections, such as HIV, SARS-CoV-2, and influenza, can disrupt microglia function, potentially leading to neuroinflammation and cognitive decline.
- * The review explores how chronic viral infections might lead to low-grade inflammation in the brain, which could accelerate aging and contribute to neurocognitive issues.
Article Abstract
Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303900 | PMC |
| http://dx.doi.org/10.3390/cells10071836 | DOI Listing |
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