AI Article Synopsis
- Field cancerization refers to the phenomenon where cancer cells can arise from specific areas in tissues, with research focusing on the differences in cancer occurrences within the human stomach, particularly between the lesser and greater curvature.
- The study measured seven different DNA adducts in various stomach regions using advanced mass spectrometry to see if their distribution could explain why gastric cancer is more frequent in certain areas.
- The findings revealed no significant differences in the quantity and location of these DNA adducts throughout the stomach, suggesting they do not account for the preferred sites of gastric cancer occurrence.
Article Abstract
Background: Field cancerization is a popular concept regarding where cancer cells arise in a plane, such as the opened-up gastrointestinal mucosa. The geospatial distribution of DNA adducts, some of which are believed to initiate mutation, may be a clue to understanding the landscape of the preferred occurrence of gastric cancer in the human stomach, such that the occurrence is much more frequent in the lesser curvature than in the greater curvature.
Methods: Seven DNA adducts, C5-methyl-2'-deoxycytidine, 2'-deoxyinosine, C5-hydroxymethyl-2'-deoxycytidine, N6-methyl-2'-deoxyadenosine, 1,N6-etheno-2'-deoxyadenosine, N6-hydroxymethyl-2'-deoxyadenosine, and C8-oxo-2'-deoxyguanosine, from different points and zones of the human stomach were semi quantitatively measured by liquid chromatography/tandem mass spectrometry. The differences in the quantity of these DNA adducts from the lesser and greater curvature, the upper, middle and lower third zones, the anterior and posterior wall of the stomach, and the mucosae distant from and near the tumor were compared to determine whether the location preference of cancer in the stomach could be explained by the distribution of these DNA adducts. Comparisons were conducted considering the tumor locations and operation methods.
Conclusions: Regarding the DNA adducts investigated, significant differences in quantities and locations in the whole stomach were not noted; thus, these DNA adducts do not explain the preferential occurrence of cancer in particular locations of the human stomach.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345122 | PMC |
| http://dx.doi.org/10.3390/cancers13153728 | DOI Listing |
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