AI Article Synopsis
- The study investigated how various antibiotics affect immune functions, focusing on natural killer (NK) cell activity, antibody dependent cell-mediated cytotoxicity (ADCC), and immunoglobulin production.
- Nitrofurantoin was found to significantly reduce NK activity in a dose-dependent manner but did not affect spontaneous ADCC, although it did suppress interferon-enhanced ADCC.
- Other antibiotics, including chloramphenicol, tetracycline, and rifampicin, were shown to decrease immunoglobulin synthesis, highlighting potential clinical implications for treating immunocompromised patients.
Article Abstract
We studied the effects of antibiotics on natural killer (NK), antibody dependent cell-mediated cytotoxicity (ADCC) and immunoglobulin production. When human peripheral blood lymphocytes were incubated overnight with the antibiotic before the assay, nitrofurantoin significantly reduced NK but not ADCC activity. Nitrofurantoin also suppressed both spontaneous and interferon-enhanced NK activities in a dose-dependent fashion. Though it did not affect spontaneous ADCC activity, nitrofurantoin suppressed interferon enhancement of ADCC. Chloramphenicol significantly decreased the number of plaque forming cells in mice. In addition to chloramphenicol, tetracycline, rifampicin, cephalothin, polymyxin B and nitrofurantoin reduced mitogen-induced polycloned immunoglobulin synthesis. Results of this study may have clinical relevance, especially in treating immunocompromised patients.
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