AI Article Synopsis
- Six new resin glycosides, called calyhedins I-VI, were discovered in the rhizomes of Calystegia hederacea, marking the first identification of these compounds from this plant.
- The structures of these glycosides were analyzed using spectroscopic methods and chemical data, revealing macrolactone characteristics and unique sugar modifications.
- Calyhedins II and III showed significant cytotoxic effects on human leukemia cells, comparable to the standard treatment drug cisplatin.
Article Abstract
Six previously undescribed resin glycosides, calyhedins I-VI, were isolated from the rhizomes of Calystegia hederacea Wall., which are the first genuine resin glycosides isolated from C. hederacea. The structures of calyhedins I-VI were determined based on spectroscopic data and chemical evidence. All the compounds have macrolactone structures (jalapins), and their sugar moieties were partially acylated by five organic acids. Calyhedins I, II-V, and VI have 27-, 28-, and 23-membered rings, respectively, and calyhedins IV-VI are the first jalapins with a sugar chain consisting of seven monosaccharides. Additionally, the cytotoxic activity of calyhedins II and III toward HL-60 human promyelocytic leukemia cells was evaluated. Both compounds demonstrated almost the same activity as the positive control, cisplatin.
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| http://dx.doi.org/10.1016/j.phytochem.2021.112888 | DOI Listing |
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Calyhedins I-VI: Resin glycosides from the rhizomes of Calystegia hederacea.
Phytochemistry
October 2021
Faculty of Pharmaceutical Sciences, Sojo University; 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
Article Synopsis
- Six new resin glycosides, called calyhedins I-VI, were discovered in the rhizomes of Calystegia hederacea, marking the first identification of these compounds from this plant.
- The structures of these glycosides were analyzed using spectroscopic methods and chemical data, revealing macrolactone characteristics and unique sugar modifications.
- Calyhedins II and III showed significant cytotoxic effects on human leukemia cells, comparable to the standard treatment drug cisplatin.
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