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Update review on SUDEP: Risk assessment, background & seizure detection devices.

Epilepsy Behav

November 2024

Academic Center for Epileptology Kempenhaeghe, Heeze, The Netherlands; Eindhoven University of Technology, Eindhoven, The Netherlands; Department of Neurology, Ghent University Hospital, Ghent, Belgium.

Article Synopsis
  • The review examines sudden unexpected death in epilepsy (SUDEP), focusing on risk factors, scoring systems to assess risk, and mechanisms behind SUDEP occurrences.
  • Key risk factors include the presence and frequency of generalized tonic-clonic seizures (GTC), with odds ratios indicating significant risk, particularly in specific contexts like bedroom sharing.
  • Four main SUDEP risk scoring systems are discussed, highlighting their different designs and the need for further validation in general epilepsy populations, along with proposed mechanisms of SUDEP involving brainstem dysfunction and potential roles of adenosine and serotonin.
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