AI Article Synopsis
- Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are among the most common cancers, but their development mechanisms remain unclear.
- Recent research suggests that the Hippo pathway and its component YAP may contribute to skin cancer progression, although direct links have yet to be established.
- This review aims to investigate the role of the Hippo pathway in skin cancer development and its potential as a target for new therapies.
Article Abstract
Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most frequently diagnosed cancers in humans, however, their exact pathogenesis is not fully understood. In recent years, it has been hypothesized that the recently discovered Hippo pathway could play a detrimental role in cutaneous carcinogenesis, but no direct connections have been made. The Hippo pathway and its effector, YAP, are responsible for tissue growth by accelerating cell proliferation, however, YAP upregulation and overexpression have also been reported in numerous types of tumors. There is also evidence that disrupted YAP/Hippo signaling is responsible for cancer growth, invasion, and metastasis. In this short review, we will explore whether the Hippo pathway is an important regulator of skin carcinogenesis and if it could be a promising target for future therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306788 | PMC |
| http://dx.doi.org/10.3390/life11070680 | DOI Listing |
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