Species Distribution, Antifungal Susceptibility, and Molecular Epidemiology of Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand.

species represent a common cause of bloodstream infection (BSI). Given the emergence of non-albicans (NAC) associated with treatment failure, investigations into the species distribution, fungal susceptibility profile, and molecular epidemiology of pathogens are necessary to optimize the treatment of candidemia and explore the transmission of drug resistance for control management. This study evaluated the prevalence, antifungal susceptibility, and molecular characteristics of species causing BSI in a tertiary-level hospital in Bangkok, Thailand. In total, 54 isolates were recovered from 49 patients with candidemia. was the most prevalent species (33.3%), followed by (29.6%). Most species were susceptible to various antifungal agents, excluding and , which had increased rates of non-susceptibility to azoles. Most isolates were non-susceptible to echinocandins, especially caspofungin. The population structure of was highly diverse, with clade 17 predominance. GoeBURST analysis of revealed associations between genotype and fluconazole resistance in a particular clonal complex. The population structure of appeared to have a low level of genetic diversity in MLST loci. Collectively, these data might provide a fundamental database contributing to the development of novel antifungal agents and diagnostic tests.