The effect of ethanol ingestion on regional brain biogenic amine levels in cadmium exposed animals was examined. The rats were given either ethanol (1 g/kg, first week, 5 g/kg, second week and 10 g/kg for rest of the weeks) or cadmium (40 ppm in drinking water) or a combination of both for 8 weeks. Simultaneous exposure to cadmium and ethanol produced a greater elevation of norepinephrine in hypothalamus and mid brain when compared with rats receiving only cadmium. A significant elevation of 5-hydroxy-tryptamine in medulla oblongata was also noticed in cadmium and ethanol treated rats compared to cadmium alone treatment animals. The present results suggest industrial workers consuming alcohol may be more susceptible to cadmium neurotoxicity.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Metabolomics analyses and comparative insight to neuroprotective potential of unripe fruits and leaves of Citrus aurantium ethanolic extracts against cadmium-induced rat brain dysfunction: involvement of oxidative stress and akt-mediated CREB/BDNF and GSK3β/NF-κB signaling pathways.
Metab Brain Dis
January 2025
Pharmacognosy Department, National Research Centre (NRC), El Behouth St., P.O. 12622, Cairo, Egypt.
Serious neurological disorders were associated with cadmium toxicity. Hence, this research aimed to investigate the potential neuroprotective impacts of the ethanolic extracts of Citrus aurantium unripe fruits and leaves (CAF and CAL, respectively) at doses 100 and 200 mg/kg against cadmium chloride-provoked brain dysfunction in rats for 30 consecutive days. HPLC for natural pigment content revealed that CAF implied higher contents of Chlorophyll B, while the CAL has a high yield of chlorophyll A and total carotenoid.
View Article and Find Full Text PDFAmeliorative role of Tetrapleura tetraptera (Schum. & Thonn.) taub in cadmium chloride-induced oxidative stress in Drosophila melanogaster using in vivo and computational approaches.
J Trace Elem Med Biol
November 2024
Department of Biochemistry, Chrisland University, Abeokuta, Nigeria; Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-ife, Nigeria.
Article Synopsis
- Cadmium (Cd) causes oxidative stress in organisms, while the ethnomedicinal plant Tetrapleura tetraptera (Tt) is known for its high antioxidant properties and potential to treat various diseases.
- The study involved feeding Drosophila melanogaster different diets, including Tt extracts and cadmium chloride (CdCl), then measuring the impact on oxidative stress markers and fly health after a week.
- Results showed that T. tetraptera reduced oxidative stress caused by cadmium, improving antioxidant activity, enhancing levels of important compounds, and increasing the rate of offspring emergence, suggesting its potential as a treatment for oxidative stress-related issues.
Distinct lignocelluloses of plant evolution are optimally selective for complete biomass saccharification and upgrading Cd/Pb and dye adsorption via desired biosorbent assembly.
Bioresour Technol
February 2025
Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan, 430068, China. Electronic address:
In this study, 15 plant species representing plant evolution were selected, and distinct lignocellulose compositions for largely varied biomass enzymatic saccharification were detected. By comparison, the acid-pretreated lignocellulose of rice mutant was of the highest Congo-red adsorption (298 mg/g) accounting for cellulose accessibility, leading to complete cellulose hydrolysis and high bioethanol production. By conducting oxidative-catalysis with the acid-pretreated lignocellulose of moss plant, the optimal biosorbent was generated with maximum Cd/Pb adsorption (54/118 mg/g), mainly due to half-reduced cellulose polymerization degree and raised functional groups accountable for multiple physical and chemical interactions.
View Article and Find Full Text PDFPhysicochemical and Emulsifying Properties of Gum.
Scientifica (Cairo)
August 2024
Department of Pharmaceutics Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Naturally occurring hydrophilic colloids are versatile excipients in drug delivery systems. They are often used as coating materials, disintegrating agents, binders, emulsion stabilizers, and other applications. This study sought to investigate the physicochemical and emulsifying properties of gum extracted from (MA).
View Article and Find Full Text PDFBio-Based Materials as a Sustainable Solution for the Remediation of Contaminated Marine Sediments: An LCA Case Study.
Polymers (Basel)
July 2024
Department of Environmental Engineering and Management, "Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania.
Contaminated sediments may induce long-term risks to humans and ecosystems due to the accumulation of priority and emerging inorganic and organic pollutants having toxic and bio-accumulation properties that could become a secondary pollution source. This study focused on the screening of novel bio-based materials to be used in the decontamination of marine sediments considering technical and environmental criteria. It aimed to compare the environmental impacts of cellulose-based adsorbents produced at lab scale by using different syntheses protocols that involved cellulose functionalization by oxidation and branching, followed by structuring of an aerogel-like material via Soxhlet extraction and freeze-drying or their combination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!