Prepatellar Bursitis with Abscess due to .

are ubiquitous and reside as skin and mucosa commensals in animals. They are considered contaminants in clinical specimens, but significant clinical data points to their virulence and pathogenic potential over the last two decades. can cause both community-acquired and nosocomial infections. () responsible for diphtheria has declined over the previous two decades with an increase in a similar clinical syndrome by () in Europe. As per recent studies, shares similar virulence factors with . has been implicated in airway infections, skin and soft tissue infections, lymphadenitis, wound infections, and rarely necrotizing fasciitis. Pet or farm animals have been the source of these infections to humans, as per recent reports. Strains can be either toxigenic or nontoxigenic. Due to recent advances, methods to characterize strains have become easier with mass spectrometry. Antimicrobial susceptibility testing is a must for definite treatment as can be resistant to first-line antibiotic therapy. If resources are available, it is prudent to find if there is any toxin production. Here, we describe a rural farmer in central Missouri presenting with acute-onset right knee pain diagnosed with right prepatellar bursitis with abscess due to infection. He recovered with surgical debridement and antimicrobial therapy. This is the first case of causing prepatellar bursitis with an abscess as per medical literature review.