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Clinical, radiological, pathological and prognostic features of general paresis: a cohort study.
Brain
February 2025
Department of Neurology and National Center for Neurological Diseases, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
General paresis is a rare type of syphilis characterized by progressive cognitive impairment and psychiatric syndromes. It is often misdiagnosed because of its rarity and similarity with other diseases. We aimed to comprehensively investigate the clinical, radiological, pathological, and prognostic features of general paresis, and compare it with other dementias.
View Article and Find Full Text PDFNORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocol.
Epilepsia Open
January 2025
Neurology Department, Wellstar MCG Health at the Medical College of Georgia, Augusta, Georgia.
New Onset Refractory Status Epilepticus (NORSE) is a rare and severe condition characterized by refractory seizures in individuals without a prior history of epilepsy. This case report describes a 37-year-old woman diagnosed with anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody-positive encephalitis-related NORSE. Her seizures were refractory to multiple interventions, including anti-seizure medications, anesthetics, immunotherapies, a ketogenic diet, and electroconvulsive therapy.
View Article and Find Full Text PDFANTI -NMDA RECEPTOR ENCEPHALITIS: A POSSIBLE APPROACH TO DEVELOP A COST-EFFECTIVE TEST FOR ANTI NMDA RECEPTOR ANTIBODY DETECTION.
J Ayub Med Coll Abbottabad
November 2024
Department of Neurology, Shifa International Hospital, Islamabad-Pakistan.
Background: Autoimmune encephalitis (AIE) has been ranked as the third most common cause of encephalitis after viral encephalitis and acute disseminated encephalomyelitis. The estimated incidence is 5-8 cases per 100,000 population. The objective of this study was to develop a cost-effective test for detection of anti NMDA R antibodies by using in house prepared rodent brain tissue sections which could facilitate timely diagnosis and management of anti NMDA R Encephalitis, which if left undiagnosed may prove fatal.
View Article and Find Full Text PDFNeurological Complications Associated With Varicella-Zoster Virus Infection.
Cureus
October 2024
Department of Pediatrics: Pediatric Neurology, Local Healthcare Unit Alto Ave, Guimarães, PRT.
Varicella-zoster virus is a highly contagious infection that primarily affects children. It typically presents as a mild, self-limiting illness with a distinctive rash. However, severe complications can arise, with skin and soft tissue infections being the most common.
View Article and Find Full Text PDFElevated cerebrospinal fluid IgG index in herpes simplex encephalitis post-HSV-1 clearance: A preliminary study.
J Med Virol
August 2024
Department of Neurology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Article Synopsis
- Herpes simplex encephalitis (HSE) can lead to serious neurological issues, and recent studies suggest the immune response in the central nervous system may play a key role in its development.
- A study involving 176 patients suspected of having viral meningitis or encephalitis found a significant increase in the IgG index in patients who tested positive for herpes simplex virus type 1 (HSV-1) after they cleared the virus.
- The findings indicate that elevated IgG levels can occur even after the virus is gone, suggesting an immune response that doesn't rely on antibodies, which could have implications for understanding HSE's effects on the brain.
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