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| http://dx.doi.org/10.1093/eurheartj/ehab457 | DOI Listing |
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Aging results in a progressive decline in physiological function due to the deterioration of essential biological processes, such as transcription and RNA splicing, ultimately increasing mortality risk. Although proteomics is emerging as a powerful tool for elucidating the molecular mechanisms of aging, existing studies are constrained by limited proteome coverage and only observe a narrow range of lifespan. To overcome these limitations, we integrated the Orbitrap Astral Mass Spectrometer with the multiplex tandem mass tag (TMT) technology to profile the proteomes of three brain tissues (cortex, hippocampus, striatum) and kidney in the C57BL/6JN mouse model, achieving quantification of 8,954 to 9,376 proteins per tissue (cumulatively 12,749 across all tissues).
View Article and Find Full Text PDFEffect of Electroacupuncture Treatment on Bladder Function and Urodynamic Features of Neurogenic Bladder in Stroke: A Retrospective Study.
Arch Esp Urol
December 2024
Department of Urology, Jinggangshan University Affiliated Hospital, 343000 Ji'an, Jiangxi, China.
Background: Neurogenic bladder dysfunction is a common consequence of stroke, and it substantially impacts the quality of life and functional independence of affected individuals. Traditional treatment modalities have limitations in achieving optimal outcomes. This study aims to explore the effects of electroacupuncture treatment on bladder function and neurogenic bladder urodynamic characteristics in stroke patients.
View Article and Find Full Text PDFKawasaki disease (KD) is a leading cause of acquired heart disease in children, often resulting in coronary artery complications such as dilation, aneurysms, and stenosis. While intravenous immunoglobulin (IVIG) is effective in reducing immunologic inflammation, 10-15% of patients do not respond to initial therapy, and some show resistance even after two consecutive treatments. Predicting which patients will not respond to these two IVIG treatments is crucial for guiding treatment strategies and improving outcomes.
View Article and Find Full Text PDFThe fastest nonprofessional age group IRONMAN triathletes in the world originate from Europe.
Sci Rep
January 2025
Department of Physical Education, States University of Pará, Pará, Brazil.
It is well known that elite athletes of specific ethnicities and/or nationalities dominate certain sports disciplines (e.g., East Africans in marathon running).
View Article and Find Full Text PDFDevelopment and Clinical Evaluation of a Contrast Optimizer for Contrast-Enhanced CT Imaging of the Liver.
J Comput Assist Tomogr
November 2024
From the Carl E. Ravin Advanced Imaging Labs, Center for Virtual Imaging Trials, Department of Radiology.
Objective: Patient characteristics, iodine injection, and scanning parameters can impact the quality and consistency of contrast enhancement of hepatic parenchyma in CT imaging. Improving the consistency and adequacy of contrast enhancement can enhance diagnostic accuracy and reduce clinical practice variability, with added positive implications for safety and cost-effectiveness in the use of contrast medium. We developed a clinical tool that uses patient attributes (height, weight, sex, age) to predict hepatic enhancement and suggest alternative injection/scanning parameters to optimize the procedure.
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