AI Article Synopsis
- Excessive prenatal exposure to opioids may cause Neonatal Opioid Withdrawal Syndrome (NOWS), leading to treatment needs in affected infants.!
- An RNA sequencing analysis of placental tissue from mothers with opioid use disorder identified 93 differentially expressed genes in infants with NOWS compared to unexposed controls, with a significant number being downregulated.!
- The study highlights specific genes, particularly CYP1A1 and others, that may play a crucial role in the development of NOWS, providing new insights into its genetic mechanisms. !
Article Abstract
Excessive prenatal opioid exposure may lead to the development of Neonatal Opioid Withdrawal Syndrome (NOWS). RNA-seq was done on 64 formalin-fixed paraffin-embedded placental tissue samples from 32 mothers with opioid use disorder, with newborns with NOWS that required treatment, and 32 prenatally unexposed controls. We identified 93 differentially expressed genes in the placentas of infants with NOWS compared to unexposed controls. There were 4 up- and 89 downregulated genes. Among these, 7 genes CYP1A1, APOB, RPH3A, NRXN1, LINC01206, AL157396.1, UNC80 achieved an FDR p-value of <0.01. The remaining 87 genes were significant with FDR p-value <0.05. The 4 upregulated, CYP1A1, FP671120.3, RAD1, RN7SL856P, and the 10 most significantly downregulated genes were RNA5SP364, GRIN2A, UNC5D, DMBT1P1, MIR3976HG, LINC02199, LINC02822, PANTR1, AC012178.1, CTNNA2. Ingenuity Pathway Analysis identified the 7 most likely to play an important role in the etiology of NOWS. Our study expands insights into the genetic mechanisms of NOWS development.
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| http://dx.doi.org/10.1016/j.ygeno.2021.08.001 | DOI Listing |
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