AI Article Synopsis
- - Animals use different hemispheres of the brain to control their left and right limbs for coordinated movements, but how this coordination happens is not fully understood.
- - Researchers created a bimanual-press task for mice to study how they press left and right pedals in a specific order, revealing unique motor signals generated in the brain for each limb's movement.
- - The study found that signals for moving one limb can influence the movement of the other limb through connections between the brain’s motor cortices, highlighting a complex coordination mechanism for sequential movements.
Article Abstract
Animals precisely coordinate their left and right limbs for various adaptive purposes. While the left and right limbs are clearly controlled by different cortical hemispheres, the neural mechanisms that determine the action sequence between them remains elusive. Here, we have established a novel head-fixed bimanual-press (biPress) sequence task in which mice sequentially press left and right pedals with their forelimbs in a predetermined order. Using this motor task, we found that the motor cortical neurons responsible for the first press (1P) also generate independent motor signals for the second press (2P) by the opposite forelimb during the movement transitions between forelimbs. Projection-specific calcium imaging and optogenetic manipulation revealed these motor signals are transferred from one motor cortical hemisphere to the other via corticocortical projections. Together, our results suggest the motor cortices coordinate sequential bimanual movements through corticocortical pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387156 | PMC |
| http://dx.doi.org/10.1523/ENEURO.0200-21.2021 | DOI Listing |
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