The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.
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| http://dx.doi.org/10.1016/j.cmet.2021.07.004 | DOI Listing |
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Relaxation moduli of glass-forming systems: temperature effects and fluctuations.
Soft Matter
September 2021
Institut Charles Sadron, CNRS - UPR 22, Université de Strasbourg, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
Equilibrium and dynamical properties of a two-dimensional polydisperse colloidal model system are characterized by means of molecular dynamics (MD) and Monte Carlo (MC) simulations. We employed several methods to prepare quasi-equilibrated systems: in particular, by slow cooling and tempering with MD (method SC-MD), and by tempering with MC dynamics involving swaps of particle diameters (methods Sw-MD, Sw-MC). It is revealed that the Sw-methods are much more efficient for equilibration below the glass transition temperature T leading to denser and more rigid systems which show much slower self-diffusion and shear-stress relaxation than their counterparts prepared with the SC-MD method.
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