Background: Psoriasis is a complex autoimmune multifactorial disease induced by interaction of environmental and genetic factors. This research aimed to clarify the association of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) polymorphisms with susceptibility to psoriasis.
Methods: This case-control study involved 150 patients diagnosed with psoriasis and 100 age- and gender-matched apparently healthy individuals. NLRP3 (rs10754558) polymorphism was done by real time PCR and PTPN22 1858C/T (rs2476601) genotype was identified by tetra-primer amplification refractory mutation system-polymerase chain reaction (PCR) method.
Results: The genotypes distribution of NLRP3 (rs10754558) were significantly associated with psoriasis (<0.0001). Whereas for PTPN22 (1858C/T) (rs2476601), no significance was found (=0.09). NLRP3 (rs10754558) GC genotype revealed a significant association with psoriasis (<0.0001), mainly among male (=0.004) patients with mild psoriasis (=0.001) and affected extremities (=0.0001).
Conclusion: We can conclude that the NLRP3 (rs10754558) GC genotype may play a role in psoriasis susceptibility among male Egyptian populations with affected extremities. Future studies must evaluate its role in the prevention or the treatment of psoriasis.
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| http://dx.doi.org/10.2147/TACG.S319065 | DOI Listing |
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