Introduction: Previous studies have suggested the involvement of chronic low-grade inflammation in the pathogenesis of diabetic neuropathy (DNP). However, none of these studies have examined the levels of monocyte chemoattractant protein-1 (MCP-1) in type 2 diabetes mellitus (T2DM) patients with confirmed diagnosis of neuropathy. Therefore, the present study aims to investigate the levels of MCP-1 along with IL-6, IL-8 and TGF-β in patients with T2DM and confirmed neuropathy and identify correlations, if any, between MCP-1 and other parameters.
Methods: A single center cross-sectional clinical study was conducted at University Hospital Sharjah (UHS) and University of Sharjah. One hundred and two patients with T2DM were recruited from diabetes clinics at UHS and were stratified into different groups based on diagnosis of DNP and other parameters. Several analyses were conducted to evaluate and compare the levels of MCP-1, IL-6, IL-8, and TGF-β across these groups of patients and identify correlations, if any, between MCP-1 and other variables.
Results: A significant increase was found in the levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP (p=0.002, p-adj=0.007). Further analysis has shown that levels of IL-8 (p=0.008) and TGF-β (p=0.06) were increased and decreased, respectively, in patients with DNP compared to patients without DNP. Moreover, strong correlations were found between MCP-1, IL-8 and TGF-β levels.
Conclusion: The key finding of the present study is the significant elevation in levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP and IL-8 and TGF-β were strong predictors of MCP-1 increased levels.
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http://dx.doi.org/10.2147/DMSO.S319863 | DOI Listing |
Korean J Pain
December 2024
School of Anesthesia, Shanxi Medical University, Shanxi, China.
Background: Diabetic pain patients have increased pain at night. Exosomes can relieve neuropathic pain. This study aimed to investigate the efficacy of exosome administration at different time points in relieving diabetic neuropathic pain (DNP) in rats.
View Article and Find Full Text PDFCrohns Colitis 360
October 2024
Division of Gastroenterology, University of Washington, Seattle, WA, USA.
Background: Medically refractory Crohn's disease (CD) is associated with a high risk of complications. Mycophenolate mofetil (MMF), a small molecule immunosuppressant, has limited data in patients with CD, and objective endoscopic response to MMF has not been reported.
Aims: We evaluated the safety and clinical, endoscopic, and biochemical effectiveness of off-label MMF for refractory CD as monotherapy or in combination with a biologic in patients with CD.
J Am Chem Soc
December 2024
Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France.
NMR is a central tool in the field of metabolomics, thanks to its ability to provide valuable structural and quantitative information with high precision. Most NMR-based metabolomics studies rely on 1D H detection, which is heavily limited by strong peak overlap. C NMR benefits from a wider spectral dispersion and narrower signal line width but is barely used in metabolomics due to its low sensitivity.
View Article and Find Full Text PDFJ Nurs Adm
October 2024
Author Affiliations: Assistant Dean (Dr Hampton), MSN and DNP Programs, Academic Program Coordinator, Graduate Leadership Programs, and Associate Professor, Associate Dean for Graduate Programs and Practice and Professor (Dr Melander), and Professor and Biostatistician (Dr Rayens), University of Kentucky College of Nursing, Lexington.
Objective: The purpose of this study was to assess the association of educational level, work experience, and other demographic factors with the perceived impact of nurse practitioner role effectiveness.
Background: Nurse practitioners (NPs) bring value by impacting patient and organizational outcomes in multiple ways. Employers report difficulties differentiating between how MSN- versus DNP-educated NPs affect patient and organizational outcomes.
J Christ Nurs
December 2024
Shauna L. Meilner, DNP, RN, CCRN, CNE, provides hands-on patient care and works with nurse residents in the Surgery and Education departments at Delta Health hospital. She also serves as affiliate faculty at Colorado Christian University.
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