What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes.

Anaerobe

Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Biodiscovery Institute, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, NG7 2RD, UK. Electronic address:

Published: October 2021

Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20291 is taken into account in research outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556159PMC
http://dx.doi.org/10.1016/j.anaerobe.2021.102422DOI Listing

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