AI Article Synopsis
- Research on medical countermeasures (MCMs) for lung injuries caused by radiation requires reliable animal models that accurately simulate human conditions to ensure the findings are applicable to humans.
- Understanding the strengths and weaknesses of different animal models is crucial for demonstrating the effectiveness of these countermeasures in treating radiation-induced damage.
- A meeting held on March 20, 2019, by the Radiation and Nuclear Countermeasures Program gathered various stakeholders to discuss research gaps and the use of animal models in studying radiation-induced lung damage.
Article Abstract
Research and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Institute of Allergy and Infectious Diseases (NIAID) brought together medical, scientific and regulatory communities, including academic and industry subject matter experts, and government stakeholders from the Food and Drug Administration (FDA) and the Biomedical Advanced Research and Development Authority (BARDA), to identify critical research gaps, discuss current clinical practices for various forms of pulmonary damage, and consider available animal models for radiation-induced lung injury.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648426 | PMC |
| http://dx.doi.org/10.1667/RADE-21-00127.1 | DOI Listing |
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